| 8/27/2022 | Friends (4-7) | 31 | at | Panhandle State | 14 | KCAC | ||
| 9/3/2022 | Panhandle State | 13 | at | Langston (6-4,5-4) | 48 | |||
| 9/10/2022 | Panhandle State | 0 | at | Texas Wesleyan (8-2,7-2) | 52 | |||
| 9/17/2022 | Texas College (1-9,1-8) | 6 | at | Panhandle State | 53 | |||
| 9/24/2022 | Panhandle State | 26 | at | Lyon (1-9,0-9) | 19 | |||
| 10/1/2022 | Louisiana College (7-4,6-3) | 16 | at | Panhandle State | 28 | |||
| 10/8/2022 | Wayland Baptist (2-8,2-7) | 10 | at | Panhandle State | 38 | |||
| 10/15/2022 | Panhandle State | 18 | at | Southwestern Assemblies of God (7-4,6-3) | 41 | |||
| 10/29/2022 | Panhandle State | 0 | at | Arizona Christian (8-3,7-2) | 41 | |||
| 11/12/2022 | Ottawa AZ (7-2,7-2) | 40 | at | Panhandle State | 6 |
| vs Panhandle State | vs Other Opponents | Panhandle State compared to OOs | |
| Record: | 6-4 | 45-48 | |
| Points Scored: | 30.40 | 29.86 | -0.54 |
| Points Allowed: | 19.60 | 29.92 | -10.32 |
| Margin: | 10.80 | -0.06 | -10.86 |
| Total Points: | 50.00 | 59.78 | -9.78 |