| 8/27/2022 | Hastings | 28 | at | Trinity International (1-10) | 0 | | | at MSFA |
| 9/3/2022 | Hastings | 10 | at | Midland U. (8-3,7-3) | 14 | | | |
| 9/10/2022 | Mount Marty (3-8,2-8) | 20 | at | Hastings | 45 | | | |
| 9/17/2022 | Hastings | 21 | at | Concordia NE (4-6,4-6) | 17 | | | |
| 9/24/2022 | Dakota Wesleyan (2-9,2-8) | 13 | at | Hastings | 32 | | | |
| 10/1/2022 | Briar Cliff (1-10,1-9) | 9 | at | Hastings | 28 | | | |
| 10/8/2022 | Hastings | 17 | at | Morningside (11-1,10-0) | 70 | | | |
| 10/15/2022 | Doane (4-6,4-6) | 9 | at | Hastings | 14 | | | |
| 10/22/2022 | Hastings | 23 | at | Jamestown (4-7,3-7) | 16 | | | |
| 11/5/2022 | Hastings | 7 | at | Dordt (7-3,7-3) | 49 | | | |
| 11/12/2022 | Northwestern IA (13-1,9-1) | 41 | at | Hastings | 10 | | | |