| 8/25/2022 | Dakota Wesleyan | 19 | at | Dakota State | 29 | | | @ NSAA |
| Valley City State | 24 | at | Jamestown | 27 | OT | | NSAA |
| Mount Marty | 42 | at | Presentation | 10 | | | @ NSAA |
| 8/27/2022 | Waldorf | 42 | at | Briar Cliff | 24 | | | NSAA |
| St Mary KS | 10 | at | Midland U. | 64 | | | KCAC |
| Hastings | 28 | at | Trinity International | 0 | | | @ MSFA |
| 9/3/2022 | Dordt | 35 | at | Briar Cliff | 13 | | | |
| Concordia NE | 10 | at | Doane | 12 | | | |
| Dakota Wesleyan | 30 | at | Jamestown | 34 | | | |
| Hastings | 10 | at | Midland U. | 14 | | | |
| Northwestern IA | 29 | at | Morningside | 30 | | | |
| 9/10/2022 | Jamestown | 25 | at | Briar Cliff | 31 | | | |
| Midland U. | 20 | at | Doane | 6 | | | |
| Morningside | 49 | at | Dordt | 21 | | | |
| Mount Marty | 20 | at | Hastings | 45 | | | |
| Dakota Wesleyan | 7 | at | Northwestern IA | 54 | | | |
| 9/17/2022 | Hastings | 21 | at | Concordia NE | 17 | | | |
| Dordt | 38 | at | Dakota Wesleyan | 7 | | | |
| Northwestern IA | 48 | at | Jamestown | 3 | | | |
| Briar Cliff | 23 | at | Morningside | 59 | | | |
| Midland U. | 20 | at | Mount Marty | 7 | | | |
| 9/24/2022 | Mount Marty | 41 | at | Briar Cliff | 19 | | | |
| Doane | 13 | at | Dordt | 10 | OT | | |
| Dakota Wesleyan | 13 | at | Hastings | 32 | | | |
| Jamestown | 10 | at | Midland U. | 21 | | | |
| Concordia NE | 10 | at | Northwestern IA | 34 | | | |
| 10/1/2022 | Concordia NE | 20 | at | Dakota Wesleyan | 12 | | | |
| Briar Cliff | 9 | at | Hastings | 28 | | | |
| Doane | 17 | at | Jamestown | 41 | | | |
| Morningside | 47 | at | Midland U. | 12 | | | |
| Mount Marty | 8 | at | Northwestern IA | 52 | | | |
| 10/7/2022 | Dordt | 44 | at | Mount Marty | 29 | | | |
| 10/8/2022 | Midland U. | 56 | at | Briar Cliff | 21 | | | |
| Jamestown | 15 | at | Concordia NE | 30 | | | |
| Dakota Wesleyan | 13 | at | Doane | 16 | | | |
| Hastings | 17 | at | Morningside | 70 | | | |
| 10/15/2022 | Mount Marty | 24 | at | Concordia NE | 47 | | | |
| Briar Cliff | 24 | at | Dakota Wesleyan | 31 | | | |
| Northwestern IA | 23 | at | Dordt | 0 | | | |
| Doane | 9 | at | Hastings | 14 | | | |
| Morningside | 59 | at | Jamestown | 7 | | | |
| 10/22/2022 | Dordt | 29 | at | Concordia NE | 28 | | | |
| Midland U. | 22 | at | Dakota Wesleyan | 13 | | | |
| Northwestern IA | 59 | at | Doane | 10 | | | |
| Hastings | 23 | at | Jamestown | 16 | | | |
| Morningside | 77 | at | Mount Marty | 0 | | | |
| 10/29/2022 | Jamestown | 24 | at | Dordt | 44 | | | |
| Concordia NE | 31 | at | Midland U. | 41 | | | |
| Dakota Wesleyan | 14 | at | Morningside | 70 | | | |
| Doane | 16 | at | Mount Marty | 27 | | | |
| Briar Cliff | 7 | at | Northwestern IA | 56 | | | |
| 11/5/2022 | Concordia NE | 45 | at | Briar Cliff | 10 | | | |
| Mount Marty | 34 | at | Dakota Wesleyan | 38 | | | |
| Hastings | 7 | at | Dordt | 49 | | | |
| Doane | 3 | at | Morningside | 58 | | | |
| Midland U. | 10 | at | Northwestern IA | 42 | | | |
| 11/12/2022 | Morningside | 55 | at | Concordia NE | 18 | | | |
| Briar Cliff | 14 | at | Doane | 28 | | | |
| Northwestern IA | 41 | at | Hastings | 10 | | | |
| Dordt | 17 | at | Midland U. | 8 | | | |
| Jamestown | 23 | at | Mount Marty | 20 | | | |
| 11/19/2022 | Arizona Christian | 18 | at | Morningside | 35 | | NAIA Championship Round 1 | Soon |
| Dickinson State | 7 | at | Northwestern IA | 49 | | NAIA Championship Round 1 | NSAA |
| 11/26/2022 | Keiser | 29 | at | Morningside | 28 | | NAIA Quarterfinal | Sun |
| Marian IN | 27 | at | Northwestern IA | 52 | | NAIA Quarterfinal | MSFA |
| 12/3/2022 | Indiana Wesleyan | 7 | at | Northwestern IA | 38 | | NAIA Semifinals | MSFA |
| 12/17/2022 | Northwestern IA | 35 | vs | Keiser | 25 | | NAIA Championship - Durham NC | vs Sun |