| 8/25/2022 | Valley City State (5-5) | 24 | at | Jamestown | 27 | OT | NSAA | |
| 9/3/2022 | Dakota Wesleyan (2-9,2-8) | 30 | at | Jamestown | 34 | |||
| 9/10/2022 | Jamestown | 25 | at | Briar Cliff (1-10,1-9) | 31 | |||
| 9/17/2022 | Northwestern IA (13-1,9-1) | 48 | at | Jamestown | 3 | |||
| 9/24/2022 | Jamestown | 10 | at | Midland U. (8-3,7-3) | 21 | |||
| 10/1/2022 | Doane (4-6,4-6) | 17 | at | Jamestown | 41 | |||
| 10/8/2022 | Jamestown | 15 | at | Concordia NE (4-6,4-6) | 30 | |||
| 10/15/2022 | Morningside (11-1,10-0) | 59 | at | Jamestown | 7 | |||
| 10/22/2022 | Hastings (7-4,6-4) | 23 | at | Jamestown | 16 | |||
| 10/29/2022 | Jamestown | 24 | at | Dordt (7-3,7-3) | 44 | |||
| 11/12/2022 | Jamestown | 23 | at | Mount Marty (3-8,2-8) | 20 |
| vs Jamestown | vs Other Opponents | Jamestown compared to OOs | |
| Record: | 7-4 | 58-52 | |
| Points Scored: | 31.55 | 27.11 | -4.44 |
| Points Allowed: | 20.45 | 24.83 | -4.38 |
| Margin: | 11.10 | 2.28 | -8.82 |
| Total Points: | 52.00 | 51.94 | 0.06 |