| 9/3/2022 | Concordia NE (4-6,4-6) | 10 | at | Doane | 12 | |||
| 9/10/2022 | Midland U. (8-3,7-3) | 20 | at | Doane | 6 | |||
| 9/24/2022 | Doane | 13 | at | Dordt (7-3,7-3) | 10 | OT | ||
| 10/1/2022 | Doane | 17 | at | Jamestown (4-7,3-7) | 41 | |||
| 10/8/2022 | Dakota Wesleyan (2-9,2-8) | 13 | at | Doane | 16 | |||
| 10/15/2022 | Doane | 9 | at | Hastings (7-4,6-4) | 14 | |||
| 10/22/2022 | Northwestern IA (13-1,9-1) | 59 | at | Doane | 10 | |||
| 10/29/2022 | Doane | 16 | at | Mount Marty (3-8,2-8) | 27 | |||
| 11/5/2022 | Doane | 3 | at | Morningside (11-1,10-0) | 58 | |||
| 11/12/2022 | Briar Cliff (1-10,1-9) | 14 | at | Doane | 28 |
| vs Doane | vs Other Opponents | Doane compared to OOs | |
| Record: | 6-4 | 54-48 | |
| Points Scored: | 26.60 | 28.61 | 2.01 |
| Points Allowed: | 13.00 | 26.52 | -13.52 |
| Margin: | 13.60 | 2.09 | -11.51 |
| Total Points: | 39.60 | 55.13 | -15.53 |