| 9/3/2022 | Alma (11-1) | 16 | at | Ohio Northern | 13 | OT | MIAA | |
| 9/10/2022 | Ohio Northern | 28 | at | Capital (0-10,0-9) | 13 | |||
| 9/17/2022 | Ohio Northern | 3 | at | Heidelberg (7-3,6-3) | 37 | |||
| 9/24/2022 | Ohio Northern | 31 | at | Baldwin-Wallace (7-3,7-2) | 35 | |||
| 10/1/2022 | Mount Union (14-1,9-0) | 45 | at | Ohio Northern | 0 | |||
| 10/15/2022 | John Carroll (8-2,8-1) | 24 | at | Ohio Northern | 7 | |||
| 10/22/2022 | Muskingum (5-5,4-5) | 23 | at | Ohio Northern | 7 | |||
| 10/29/2022 | Ohio Northern | 10 | at | Marietta (6-4,5-4) | 27 | |||
| 11/5/2022 | Ohio Northern | 42 | at | Otterbein (2-8,1-8) | 7 | |||
| 11/12/2022 | Wilmington (3-7,2-7) | 13 | at | Ohio Northern | 21 |
| vs Ohio Northern | vs Other Opponents | Ohio Northern compared to OOs | |
| Record: | 7-3 | 56-41 | |
| Points Scored: | 24.00 | 29.44 | 5.44 |
| Points Allowed: | 16.20 | 24.71 | -8.51 |
| Margin: | 7.80 | 4.73 | -3.07 |
| Total Points: | 40.20 | 54.15 | -13.95 |