| 9/3/2022 | Otterbein | 21 | at | Ohio Wesleyan (6-4) | 13 | at NCA | ||
| 9/10/2022 | Heidelberg (7-3,6-3) | 34 | at | Otterbein | 7 | |||
| 9/17/2022 | Otterbein | 26 | at | Wilmington (3-7,2-7) | 32 | |||
| 9/24/2022 | Marietta (6-4,5-4) | 27 | at | Otterbein | 10 | |||
| 10/1/2022 | Capital (0-10,0-9) | 28 | at | Otterbein | 35 | |||
| 10/8/2022 | Otterbein | 35 | at | Muskingum (5-5,4-5) | 41 | 2OT | ||
| 10/22/2022 | Otterbein | 14 | at | Baldwin-Wallace (7-3,7-2) | 35 | |||
| 10/29/2022 | Mount Union (14-1,9-0) | 59 | at | Otterbein | 0 | |||
| 11/5/2022 | Ohio Northern (3-7,3-6) | 42 | at | Otterbein | 7 | |||
| 11/12/2022 | Otterbein | 7 | at | John Carroll (8-2,8-1) | 62 |
| vs Otterbein | vs Other Opponents | Otterbein compared to OOs | |
| Record: | 8-2 | 51-44 | |
| Points Scored: | 37.30 | 27.21 | -10.09 |
| Points Allowed: | 16.20 | 23.25 | -7.05 |
| Margin: | 21.10 | 3.96 | -17.14 |
| Total Points: | 53.50 | 50.46 | 3.04 |