| 9/10/2022 | Ohio Wesleyan (6-4) | 21 | at | Illinois Wesleyan | 45 | NCA | ||
| 9/17/2022 | Illinois Wesleyan | 7 | at | Wheaton (8-3,8-1) | 42 | |||
| 9/24/2022 | Carroll WI (6-4,5-4) | 21 | at | Illinois Wesleyan | 26 | |||
| 10/1/2022 | Millikin (4-6,3-6) | 24 | at | Illinois Wesleyan | 38 | |||
| 10/8/2022 | Illinois Wesleyan | 14 | at | Washington U (8-3,7-2) | 59 | |||
| 10/15/2022 | North Park (1-9,1-8) | 34 | at | Illinois Wesleyan | 43 | |||
| 10/22/2022 | Carthage (3-7,3-6) | 0 | at | Illinois Wesleyan | 55 | |||
| 10/29/2022 | Illinois Wesleyan | 21 | at | Augustana IL (5-5,4-5) | 24 | |||
| 11/5/2022 | North Central (15-0,9-0) | 68 | at | Illinois Wesleyan | 3 | |||
| 11/12/2022 | Illinois Wesleyan | 21 | at | Elmhurst (0-10,0-9) | 17 |
| vs Illinois Wesleyan | vs Other Opponents | Illinois Wesleyan compared to OOs | |
| Record: | 4-6 | 52-45 | |
| Points Scored: | 31.00 | 31.09 | 0.09 |
| Points Allowed: | 27.30 | 27.49 | -0.19 |
| Margin: | 3.70 | 3.60 | -0.10 |
| Total Points: | 58.30 | 58.58 | -0.28 |