| 9/3/2022 | Carthage | 0 | at | Albion (9-1) | 52 | at MIAA | ||
| 9/17/2022 | North Central (15-0,9-0) | 59 | at | Carthage | 7 | |||
| 9/24/2022 | Washington U (8-3,7-2) | 45 | at | Carthage | 16 | |||
| 10/1/2022 | Carthage | 57 | at | Elmhurst (0-10,0-9) | 21 | |||
| 10/8/2022 | Carthage | 33 | at | North Park (1-9,1-8) | 14 | |||
| 10/15/2022 | Wheaton (8-3,8-1) | 59 | at | Carthage | 24 | |||
| 10/22/2022 | Carthage | 0 | at | Illinois Wesleyan (6-4,5-4) | 55 | |||
| 10/29/2022 | Carthage | 14 | at | Carroll WI (6-4,5-4) | 59 | |||
| 11/5/2022 | Carthage | 37 | at | Augustana IL (5-5,4-5) | 30 | |||
| 11/12/2022 | Millikin (4-6,3-6) | 17 | at | Carthage | 6 |
| vs Carthage | vs Other Opponents | Carthage compared to OOs | |
| Record: | 7-3 | 55-42 | |
| Points Scored: | 41.10 | 31.35 | -9.75 |
| Points Allowed: | 19.40 | 26.81 | -7.41 |
| Margin: | 21.70 | 4.54 | -17.16 |
| Total Points: | 60.50 | 58.16 | 2.34 |