| 9/3/2022 | Otterbein (2-8) | 21 | at | Ohio Wesleyan | 13 | OAC | ||
| 9/10/2022 | Ohio Wesleyan | 21 | at | Illinois Wesleyan (6-4) | 45 | at CCIW | ||
| 9/24/2022 | Ohio Wesleyan | 41 | at | Kenyon (3-7,2-6) | 14 | |||
| 10/1/2022 | Ohio Wesleyan | 35 | at | Wooster (6-4,4-4) | 7 | |||
| 10/8/2022 | Denison (8-2,6-2) | 7 | at | Ohio Wesleyan | 41 | |||
| 10/15/2022 | Ohio Wesleyan | 24 | at | Wabash (7-3,6-2) | 41 | |||
| 10/22/2022 | DePauw (9-2,7-1) | 22 | at | Ohio Wesleyan | 21 | |||
| 10/29/2022 | Oberlin (0-10,0-8) | 0 | at | Ohio Wesleyan | 77 | |||
| 11/5/2022 | Ohio Wesleyan | 14 | at | Wittenberg (5-5,4-4) | 7 | |||
| 11/12/2022 | Hiram (2-8,1-7) | 21 | at | Ohio Wesleyan | 47 |
| vs Ohio Wesleyan | vs Other Opponents | Ohio Wesleyan compared to OOs | |
| Record: | 4-6 | 44-47 | |
| Points Scored: | 18.50 | 30.60 | 12.10 |
| Points Allowed: | 33.40 | 31.91 | 1.49 |
| Margin: | -14.90 | -1.31 | 13.59 |
| Total Points: | 51.90 | 62.51 | -10.61 |