| 9/3/2022 | Kutztown (8-3) | 0 | at | Assumption | 3 | PSAC | ||
| 9/9/2022 | Assumption | 17 | at | Merrimack (8-3) | 45 | at NE | ||
| 9/24/2022 | Assumption | 26 | at | Pace (6-4,4-4) | 14 | |||
| 10/1/2022 | Assumption | 28 | at | Southern Connecticut (3-8,2-6) | 14 | |||
| 10/9/2022 | Franklin Pierce (2-8,1-6) | 14 | at | Assumption | 28 | |||
| 10/15/2022 | Bentley (7-3,6-2) | 10 | at | Assumption | 3 | |||
| 10/22/2022 | Assumption | 24 | at | American Int'l (1-9,1-7) | 7 | |||
| 10/29/2022 | New Haven (8-3,7-1) | 13 | at | Assumption | 14 | |||
| 11/5/2022 | Assumption | 21 | at | Saint Anselm (6-4,4-4) | 12 | |||
| 11/12/2022 | Assumption | 65 | at | Post (0-10) | 21 | at D2Ind | ||
| 11/19/2022 | Slippery Rock (10-3) | 17 | at | Assumption | 14 | D2 Championship Round 1 | PSAC |
| vs Assumption | vs Other Opponents | Assumption compared to OOs | |
| Record: | 3-8 | 56-50 | |
| Points Scored: | 15.18 | 24.02 | 8.84 |
| Points Allowed: | 22.09 | 23.58 | -1.49 |
| Margin: | -6.91 | 0.44 | 7.35 |
| Total Points: | 37.27 | 47.60 | -10.33 |