| 9/1/2022 | Seton Hill | 11 | at | Wheeling (7-4) | 25 | at MtnE | ||
| 9/10/2022 | Seton Hill | 17 | at | Shippensburg (5-6,5-5) | 36 | |||
| 9/17/2022 | East Stroudsburg (4-7,4-6) | 22 | at | Seton Hill | 7 | |||
| 9/24/2022 | Seton Hill | 2 | at | Slippery Rock (10-3,8-3) | 30 | |||
| 10/1/2022 | Seton Hill | 10 | at | Gannon (8-3,7-3) | 21 | |||
| 10/8/2022 | Clarion (3-8,3-7) | 40 | at | Seton Hill | 13 | |||
| 10/15/2022 | California PA (6-5,5-5) | 21 | at | Seton Hill | 14 | |||
| 10/22/2022 | Seton Hill | 7 | at | Indiana PA (10-2,9-2) | 44 | |||
| 10/29/2022 | Seton Hill | 45 | at | Edinboro (5-6,4-6) | 14 | |||
| 11/5/2022 | Mercyhurst (2-9,1-9) | 0 | at | Seton Hill | 7 | |||
| 11/12/2022 | Millersville (5-6,5-5) | 14 | at | Seton Hill | 10 |
| vs Seton Hill | vs Other Opponents | Seton Hill compared to OOs | |
| Record: | 9-2 | 56-57 | |
| Points Scored: | 24.27 | 25.29 | 1.02 |
| Points Allowed: | 13.00 | 24.68 | -11.68 |
| Margin: | 11.27 | 0.61 | -10.66 |
| Total Points: | 37.27 | 49.97 | -12.70 |