| 9/1/2022 | Millersville | 10 | at | Saint Anselm (6-4) | 28 | at NE10 | ||
| 9/10/2022 | Gannon (8-3,7-3) | 16 | at | Millersville | 10 | |||
| 9/17/2022 | Slippery Rock (10-3,8-3) | 45 | at | Millersville | 14 | |||
| 9/24/2022 | Millersville | 14 | at | West Chester (7-4,6-4) | 26 | |||
| 10/1/2022 | Millersville | 42 | at | Lock Haven (1-10,0-10) | 12 | |||
| 10/8/2022 | East Stroudsburg (4-7,4-6) | 14 | at | Millersville | 20 | |||
| 10/15/2022 | Millersville | 17 | at | Shepherd (13-2,11-1) | 55 | |||
| 10/22/2022 | Shippensburg (5-6,5-5) | 14 | at | Millersville | 17 | |||
| 10/29/2022 | Kutztown (8-3,8-2) | 20 | at | Millersville | 13 | |||
| 11/5/2022 | Millersville | 25 | at | Bloomsburg (4-7,4-6) | 17 | |||
| 11/12/2022 | Millersville | 14 | at | Seton Hill (2-9,2-8) | 10 |
| vs Millersville | vs Other Opponents | Millersville compared to OOs | |
| Record: | 6-5 | 62-53 | |
| Points Scored: | 23.36 | 24.54 | 1.18 |
| Points Allowed: | 17.82 | 22.90 | -5.08 |
| Margin: | 5.54 | 1.64 | -3.90 |
| Total Points: | 41.18 | 47.44 | -6.26 |