| 9/3/2022 | Mercyhurst | 45 | at | Alderson-Broaddus (0-11) | 28 | at MtnE | ||
| 9/10/2022 | Mercyhurst | 49 | at | Lock Haven (1-10,0-10) | 7 | |||
| 9/17/2022 | Kutztown (8-3,8-2) | 50 | at | Mercyhurst | 31 | |||
| 9/24/2022 | Mercyhurst | 16 | at | Indiana PA (10-2,9-2) | 33 | |||
| 10/1/2022 | Edinboro (5-6,4-6) | 16 | at | Mercyhurst | 13 | |||
| 10/8/2022 | Mercyhurst | 17 | at | Slippery Rock (10-3,8-3) | 31 | |||
| 10/15/2022 | Clarion (3-8,3-7) | 23 | at | Mercyhurst | 21 | |||
| 10/22/2022 | Mercyhurst | 14 | at | Gannon (8-3,7-3) | 49 | |||
| 10/29/2022 | California PA (6-5,5-5) | 44 | at | Mercyhurst | 20 | |||
| 11/5/2022 | Mercyhurst | 0 | at | Seton Hill (2-9,2-8) | 7 | |||
| 11/12/2022 | Bloomsburg (4-7,4-6) | 16 | at | Mercyhurst | 13 |
| vs Mercyhurst | vs Other Opponents | Mercyhurst compared to OOs | |
| Record: | 9-2 | 48-65 | |
| Points Scored: | 27.64 | 21.88 | -5.76 |
| Points Allowed: | 21.73 | 26.58 | -4.85 |
| Margin: | 5.91 | -4.70 | -10.61 |
| Total Points: | 49.37 | 48.46 | 0.91 |