| 9/1/2022 | Shepherd | 48 | at | Southern Connecticut (3-8) | 7 | | | at NE10 |
| 9/10/2022 | Edinboro (5-6,4-6) | 7 | at | Shepherd | 41 | | | |
| 9/17/2022 | California PA (6-5,5-5) | 23 | at | Shepherd | 26 | OT | | |
| 9/24/2022 | Shepherd | 42 | at | Kutztown (8-3,8-2) | 35 | | | |
| 10/1/2022 | Shepherd | 30 | at | Shippensburg (5-6,5-5) | 13 | | | |
| 10/8/2022 | Lock Haven (1-10,0-10) | 7 | at | Shepherd | 72 | | | |
| 10/15/2022 | Millersville (5-6,5-5) | 17 | at | Shepherd | 55 | | | |
| 10/22/2022 | Shepherd | 47 | at | West Chester (7-4,6-4) | 14 | | | |
| 10/29/2022 | Bloomsburg (4-7,4-6) | 10 | at | Shepherd | 55 | | | |
| 11/5/2022 | Shepherd | 37 | at | East Stroudsburg (4-7,4-6) | 14 | | | |
| 11/12/2022 | Shepherd | 21 | at | Indiana PA (10-2,9-2) | 24 | | | |
| 11/19/2022 | New Haven (8-3) | 13 | at | Shepherd | 16 | | D2 Championship Round 1 | NE10 |
| 11/26/2022 | Slippery Rock (10-3,8-3) | 27 | at | Shepherd | 37 | | D2 Playoffs Round 2 | |
| 12/3/2022 | Shepherd | 48 | at | Indiana PA (10-2,9-2) | 13 | | D2 Quarterfinals | |
| 12/10/2022 | Shepherd | 13 | at | Colorado Mines (13-3) | 44 | | D2 Semifinal | at RMAC |