| 9/2/2022 | Bentley (7-3) | 16 | at | West Chester | 17 | NE10 | ||
| 9/10/2022 | Slippery Rock (10-3,8-3) | 35 | at | West Chester | 14 | |||
| 9/17/2022 | West Chester | 29 | at | Gannon (8-3,7-3) | 23 | |||
| 9/24/2022 | Millersville (5-6,5-5) | 14 | at | West Chester | 26 | |||
| 10/1/2022 | West Chester | 16 | at | Bloomsburg (4-7,4-6) | 21 | |||
| 10/8/2022 | Shippensburg (5-6,5-5) | 20 | at | West Chester | 13 | |||
| 10/15/2022 | West Chester | 24 | at | East Stroudsburg (4-7,4-6) | 21 | |||
| 10/22/2022 | Shepherd (13-2,11-1) | 47 | at | West Chester | 14 | |||
| 10/29/2022 | Lock Haven (1-10,0-10) | 10 | at | West Chester | 58 | |||
| 11/5/2022 | West Chester | 28 | at | Kutztown (8-3,8-2) | 9 | |||
| 11/12/2022 | West Chester | 36 | at | Clarion (3-8,3-7) | 27 |
| vs West Chester | vs Other Opponents | West Chester compared to OOs | |
| Record: | 4-7 | 64-51 | |
| Points Scored: | 22.09 | 24.82 | 2.73 |
| Points Allowed: | 25.00 | 22.67 | 2.33 |
| Margin: | -2.91 | 2.15 | 5.06 |
| Total Points: | 47.09 | 47.49 | -0.40 |