| 9/4/2022 | Winston-Salem State | 21 | vs | Central State (3-7) | 41 | Canton OH | vs SIAC | |
| 9/10/2022 | Winston-Salem State | 0 | at | North Carolina Central (10-2) | 41 | at MEAC | ||
| 9/17/2022 | Winston-Salem State | 17 | at | Elizabeth City State (2-8,2-7) | 20 | |||
| 9/24/2022 | Winston-Salem State | 7 | at | Chowan (7-4,7-2) | 21 | |||
| 10/1/2022 | Lincoln PA (2-7,1-6) | at | Winston-Salem State | CCD | ||||
| 10/8/2022 | Winston-Salem State | 17 | at | Livingstone (4-6,4-5) | 20 | |||
| 10/15/2022 | Shaw (4-6,4-4) | 10 | at | Winston-Salem State | 17 | |||
| 10/22/2022 | Winston-Salem State | 41 | at | St Augustine's (1-9,1-7) | 14 | |||
| 10/29/2022 | Johnson C Smith (2-7,2-6) | 7 | at | Winston-Salem State | 28 | |||
| 11/5/2022 | Fayetteville State (9-3,8-1) | 14 | at | Winston-Salem State | 6 |
| vs Winston-Salem State | vs Other Opponents | Winston-Salem State compared to OOs | |
| Record: | 6-3 | 38-56 | |
| Points Scored: | 20.89 | 22.12 | 1.23 |
| Points Allowed: | 17.11 | 28.68 | -11.57 |
| Margin: | 3.78 | -6.56 | -10.34 |
| Total Points: | 38.00 | 50.80 | -12.80 |