| 9/1/2022 | Nebraska-Kearney (8-3,8-3) | 24 | at | Missouri Southern | 7 | | | |
| 9/10/2022 | Missouri Southern | 30 | at | Northeastern State (1-10,1-10) | 13 | | | |
| 9/17/2022 | Central Oklahoma (6-5,6-5) | 21 | at | Missouri Southern | 40 | | | |
| 9/24/2022 | Missouri Southern | 25 | at | Fort Hays State (3-8,3-8) | 24 | | | |
| 10/1/2022 | Missouri Southern | 9 | at | Pittsburg State (12-1,11-0) | 38 | | | |
| 10/8/2022 | Lincoln MO (0-11,0-11) | 14 | at | Missouri Southern | 37 | | | |
| 10/15/2022 | Missouri Southern | 17 | at | Central Missouri (4-7,4-7) | 20 | | | |
| 10/22/2022 | Emporia State (9-3,8-3) | 24 | at | Missouri Southern | 21 | | | |
| 10/29/2022 | Missouri Southern | 27 | at | Missouri Western (5-6,5-6) | 31 | | | |
| 11/5/2022 | Missouri Southern | 5 | at | Northwest Missouri State (10-3,9-2) | 27 | | | |
| 11/12/2022 | Washburn (7-4,7-4) | 37 | at | Missouri Southern | 20 | | | |