| 9/1/2022 | Fort Hays State | 19 | at | Northwest Missouri State (10-3,9-2) | 33 | | | |
| 9/8/2022 | Missouri Western (5-6,5-6) | 35 | at | Fort Hays State | 19 | | | |
| 9/17/2022 | Fort Hays State | 51 | at | Lincoln MO (0-11,0-11) | 14 | | | |
| 9/24/2022 | Missouri Southern (4-7,4-7) | 25 | at | Fort Hays State | 24 | | | |
| 10/1/2022 | Fort Hays State | 20 | at | Nebraska-Kearney (8-3,8-3) | 38 | | | |
| 10/8/2022 | Washburn (7-4,7-4) | 45 | at | Fort Hays State | 14 | | | |
| 10/15/2022 | Fort Hays State | 23 | at | Central Oklahoma (6-5,6-5) | 35 | | | |
| 10/22/2022 | Central Missouri (4-7,4-7) | 14 | at | Fort Hays State | 27 | | | |
| 10/29/2022 | Fort Hays State | 14 | at | Emporia State (9-3,8-3) | 42 | | | |
| 11/5/2022 | Northeastern State (1-10,1-10) | 14 | at | Fort Hays State | 27 | | | |
| 11/12/2022 | Fort Hays State | 14 | at | Pittsburg State (12-1,11-0) | 35 | | | |