| 9/1/2022 | Central Oklahoma (6-5,6-5) | 0 | at | Missouri Western | 35 | | | |
| 9/8/2022 | Missouri Western | 35 | at | Fort Hays State (3-8,3-8) | 19 | | | |
| 9/17/2022 | Missouri Western | 12 | at | Emporia State (9-3,8-3) | 36 | | | |
| 9/24/2022 | Washburn (7-4,7-4) | 38 | at | Missouri Western | 31 | OT | | |
| 10/1/2022 | Missouri Western | 3 | at | Northwest Missouri State (10-3,9-2) | 16 | | | |
| 10/8/2022 | Nebraska-Kearney (8-3,8-3) | 39 | at | Missouri Western | 18 | | | |
| 10/15/2022 | Missouri Western | 23 | at | Northeastern State (1-10,1-10) | 16 | | | |
| 10/22/2022 | Missouri Western | 16 | at | Pittsburg State (12-1,11-0) | 28 | | | |
| 10/29/2022 | Missouri Southern (4-7,4-7) | 27 | at | Missouri Western | 31 | | | |
| 11/5/2022 | Missouri Western | 37 | at | Central Missouri (4-7,4-7) | 40 | 2OT | | |
| 11/12/2022 | Lincoln MO (0-11,0-11) | 0 | at | Missouri Western | 41 | | | |