| 9/1/2022 | Lincoln MO (0-11,0-11) | 3 | at | Washburn | 45 | | | |
| 9/8/2022 | Washburn | 40 | at | Central Missouri (4-7,4-7) | 32 | | | |
| 9/17/2022 | Nebraska-Kearney (8-3,8-3) | 21 | at | Washburn | 13 | | | |
| 9/24/2022 | Washburn | 38 | at | Missouri Western (5-6,5-6) | 31 | OT | | |
| 10/1/2022 | Emporia State (9-3,8-3) | 42 | at | Washburn | 35 | | | |
| 10/8/2022 | Washburn | 45 | at | Fort Hays State (3-8,3-8) | 14 | | | |
| 10/15/2022 | Washburn | 30 | at | Northwest Missouri State (10-3,9-2) | 32 | | | |
| 10/22/2022 | Central Oklahoma (6-5,6-5) | 9 | at | Washburn | 37 | | | |
| 10/29/2022 | Washburn | 21 | at | Northeastern State (1-10,1-10) | 17 | | | |
| 11/5/2022 | Pittsburg State (12-1,11-0) | 37 | at | Washburn | 23 | | | |
| 11/12/2022 | Washburn | 37 | at | Missouri Southern (4-7,4-7) | 20 | | | |