| 8/25/2022 | Dakota Wesleyan | 19 | at | Dakota State | 29 | GPAC | ||
| Valley City State | 24 | at | Jamestown | 27 | OT | @ GPAC | ||
| Mount Marty | 42 | at | Presentation | 10 | GPAC | |||
| 8/27/2022 | Waldorf | 42 | at | Briar Cliff | 24 | @ GPAC | ||
| Tabor | 17 | at | Iowa Wesleyan | 13 | KCAC | |||
| Roosevelt | 55 | at | Mayville State | 14 | MSFA | |||
| 9/1/2022 | Black Hills State | 17 | at | Dickinson State | 2 | RMAC (D2) | ||
| Concordia-Moorhead | 14 | at | Valley City State | 12 | MIA (D3) | |||
| 9/3/2022 | Presentation | 29 | at | Luther | 6 | @ ARC (D3) | ||
| Iowa Wesleyan | 23 | at | Missouri Baptist | 25 | 3OT | @ MSFA | ||
| Dakota State | 7 | at | Wisconsin-La Crosse | 42 | @ WIAC (D3) | |||
| Mayville State | 31 | at | Wisconsin-Stevens Point | 24 | @ WIAC (D3) | |||
| Saint Ambrose | 13 | at | Waldorf | 33 | MSFA | |||
| 9/10/2022 | Nebraska Wesleyan | 48 | at | Mayville State | 55 | OT | ARC (D3) | |
| Dickinson State | 14 | at | Montana-Western | 35 | @ Front | |||
| Concordia-Moorhead | 42 | at | Presentation | 13 | MIA (D3) | |||
| Simpson | 21 | at | Waldorf | 54 | ARC (D3) | |||
| Iowa Wesleyan | 41 | at | Westminster MO | 6 | @ UMWAC (D3) | |||
| 9/17/2022 | Finlandia | 0 | at | Iowa Wesleyan | 55 | UMWAC (D3) | ||
| Presentation | 17 | at | Mayville State | 28 | ||||
| Dickinson State | 35 | at | Valley City State | 10 | ||||
| Dakota State | 17 | at | Waldorf | 42 | ||||
| 9/24/2022 | Iowa Wesleyan | 7 | at | Dakota State | 24 | |||
| Mayville State | 14 | at | Dickinson State | 48 | ||||
| Waldorf | 3 | at | Ferris State | 69 | @ GLIAC (D2) | |||
| Valley City State | 28 | at | Presentation | 10 | ||||
| 10/1/2022 | Dickinson State | 27 | at | Dakota State | 7 | |||
| Mayville State | 38 | at | Iowa Wesleyan | 42 | ||||
| Presentation | 3 | at | Waldorf | 48 | ||||
| 10/8/2022 | Dickinson State | 23 | at | Iowa Wesleyan | 0 | |||
| Waldorf | 28 | at | Mayville State | 21 | ||||
| Dakota State | 31 | at | Valley City State | 17 | ||||
| 10/15/2022 | Presentation | 21 | at | Dakota State | 19 | |||
| Waldorf | 7 | at | Dickinson State | 50 | ||||
| Iowa Wesleyan | 0 | at | Valley City State | 32 | ||||
| 10/22/2022 | Dakota State | 38 | at | Mayville State | 24 | |||
| Iowa Wesleyan | 49 | at | Presentation | 22 | ||||
| Valley City State | 35 | at | Waldorf | 14 | ||||
| 10/29/2022 | Valley City State | 13 | at | Dickinson State | 21 | |||
| Dakota State | 12 | at | Iowa Wesleyan | 6 | ||||
| Mayville State | 0 | at | Presentation | 21 | ||||
| 11/5/2022 | Dickinson State | 58 | at | Mayville State | 7 | |||
| Presentation | 10 | at | Valley City State | 21 | ||||
| Iowa Wesleyan | 3 | at | Waldorf | 7 | ||||
| 11/12/2022 | Waldorf | 0 | at | Dakota State | 13 | |||
| Presentation | 16 | at | Dickinson State | 73 | ||||
| Valley City State | 48 | vs | Mayville State | 40 | Fargo ND | |||
| 11/19/2022 | Dickinson State | 7 | at | Northwestern IA | 49 | NAIA Championship Round 1 | @ GPAC |