| 9/3/2022 | Nebraska Wesleyan | 31 | at | Eureka (2-8) | 6 | at NAC | ||
| 9/10/2022 | Nebraska Wesleyan | 48 | at | Mayville State (3-8) | 55 | OT | at NSAA | |
| 9/17/2022 | Dubuque (6-4,6-2) | 48 | at | Nebraska Wesleyan | 34 | |||
| 9/24/2022 | Nebraska Wesleyan | 31 | at | Loras (5-5,5-3) | 49 | |||
| 10/1/2022 | Central IA (7-3,5-3) | 58 | at | Nebraska Wesleyan | 0 | |||
| 10/15/2022 | Nebraska Wesleyan | 0 | at | Wartburg (13-1,8-0) | 65 | |||
| 10/22/2022 | Buena Vista (4-6,3-5) | 42 | at | Nebraska Wesleyan | 25 | |||
| 10/29/2022 | Nebraska Wesleyan | 41 | at | Simpson (1-9,1-7) | 74 | |||
| 11/5/2022 | Coe (7-3,6-2) | 34 | at | Nebraska Wesleyan | 14 | |||
| 11/12/2022 | Nebraska Wesleyan | 28 | at | Luther (2-8,2-6) | 35 |
| vs Nebraska Wesleyan | vs Other Opponents | Nebraska Wesleyan compared to OOs | |
| Record: | 9-1 | 41-54 | |
| Points Scored: | 46.60 | 27.35 | -19.25 |
| Points Allowed: | 25.20 | 30.85 | -5.65 |
| Margin: | 21.40 | -3.50 | -24.90 |
| Total Points: | 71.80 | 58.20 | 13.60 |