| 8/27/2022 | Roosevelt | 55 | at | Mayville State (3-8) | 14 | at NSAA | ||
| 9/17/2022 | Concordia MI (5-5,5-4) | 20 | at | Roosevelt | 28 | |||
| 9/24/2022 | Roosevelt | 42 | at | Lawrence Tech (3-7,3-6) | 28 | |||
| 10/1/2022 | Roosevelt | 20 | at | St Xavier (9-3,9-1) | 21 | |||
| 10/8/2022 | Missouri Baptist (4-7,3-6) | 3 | at | Roosevelt | 41 | |||
| 10/15/2022 | Roosevelt | 42 | at | Trinity International (1-10,1-8) | 14 | |||
| 10/22/2022 | Judson (2-8,2-8) | 12 | at | Roosevelt | 56 | |||
| 10/29/2022 | Roosevelt | 17 | at | Saint Ambrose (2-8,2-7) | 3 | |||
| 11/5/2022 | Roosevelt | 3 | at | St Francis IL (7-3,7-3) | 19 | |||
| 11/12/2022 | Olivet Nazarene (7-4,6-4) | 38 | at | Roosevelt | 31 |
| vs Roosevelt | vs Other Opponents | Roosevelt compared to OOs | |
| Record: | 3-7 | 40-56 | |
| Points Scored: | 17.20 | 24.16 | 6.96 |
| Points Allowed: | 33.50 | 29.74 | 3.76 |
| Margin: | -16.30 | -5.58 | 10.72 |
| Total Points: | 50.70 | 53.90 | -3.20 |