D2
9 Jan 2023 21:04:24
| 9/1/2022 | Notre Dame OH | 14 | at | Ashland | 31 | | | @ GMAC |
| Fairmont State | 15 | at | California PA | 35 | | | @ PSAC |
| West Liberty | 21 | at | Clarion | 14 | | | @ PSAC |
| American Int'l | 7 | at | Frostburg State | 21 | | | NE10 |
| Charleston WV | 13 | at | Gannon | 47 | | | @ PSAC |
| Glenville State | 44 | at | Quincy | 15 | | | @ GLV |
| West Virginia Wesleyan | 0 | at | Saginaw Valley State | 72 | | | @ GLIAC |
| Seton Hill | 11 | at | Wheeling | 25 | | | PSAC |
| 9/3/2022 | Mercyhurst | 45 | at | Alderson-Broaddus | 28 | | | PSAC |
| Concord | 27 | at | Emory & Henry | 20 | | | @ SAC |
| UNC Pembroke | 13 | at | Fayetteville State | 15 | | | @ CIAA |
| Shippensburg | 6 | at | West Virginia State | 29 | | | PSAC |
| 9/8/2022 | Charleston WV | 40 | at | Fairmont State | 38 | 4OT | | |
| Alderson-Broaddus | 17 | at | West Liberty | 30 | | | |
| 9/10/2022 | Glenville State | 7 | at | Concord | 21 | | | |
| West Virginia State | 7 | at | Frostburg State | 18 | | | |
| Wheeling | 14 | at | Notre Dame OH | 27 | | | |
| West Virginia Wesleyan | 26 | at | UNC Pembroke | 50 | | | |
| 9/17/2022 | Wheeling | 56 | at | Alderson-Broaddus | 41 | | | |
| Frostburg State | 34 | at | Charleston WV | 28 | | | |
| UNC Pembroke | 17 | at | Glenville State | 45 | | | |
| West Liberty | 17 | at | Notre Dame OH | 34 | | | |
| Fairmont State | 29 | at | West Virginia State | 34 | | | |
| Concord | 34 | at | West Virginia Wesleyan | 32 | | | |
| 9/24/2022 | Alderson-Broaddus | 7 | at | Charleston WV | 62 | | | |
| UNC Pembroke | 23 | at | Fairmont State | 25 | | | |
| Concord | 23 | at | Frostburg State | 22 | | | |
| West Virginia Wesleyan | 21 | at | West Liberty | 23 | | | |
| Notre Dame OH | 48 | at | West Virginia State | 13 | | | |
| Glenville State | 23 | at | Wheeling | 34 | | | |
| 9/29/2022 | Frostburg State | 9 | at | UNC Pembroke | 10 | | | |
| 10/1/2022 | West Virginia State | 30 | at | Alderson-Broaddus | 3 | | | |
| Fairmont State | 10 | at | Concord | 9 | | | |
| West Liberty | 14 | at | Glenville State | 35 | | | |
| Charleston WV | 24 | at | Notre Dame OH | 49 | | | |
| Wheeling | 37 | at | West Virginia Wesleyan | 0 | | | |
| 10/6/2022 | Fairmont State | 51 | at | Alderson-Broaddus | 7 | | | |
| 10/8/2022 | Glenville State | 34 | at | Charleston WV | 41 | | | |
| Notre Dame OH | 30 | at | Frostburg State | 33 | 2OT | | |
| Concord | 45 | at | West Liberty | 28 | | | |
| West Virginia Wesleyan | 21 | at | West Virginia State | 46 | | | |
| UNC Pembroke | 17 | at | Wheeling | 16 | | | |
| 10/13/2022 | West Liberty | 27 | at | Fairmont State | 24 | OT | | |
| West Virginia State | 24 | at | UNC Pembroke | 45 | | | |
| 10/15/2022 | Charleston WV | 60 | at | Concord | 68 | | | |
| Alderson-Broaddus | 12 | at | Glenville State | 31 | | | |
| Frostburg State | 27 | at | Wheeling | 31 | | | |
| Notre Dame OH | 41 | at | West Virginia Wesleyan | 9 | | | |
| 10/20/2022 | Fairmont State | 14 | at | Frostburg State | 16 | | | |
| 10/22/2022 | West Virginia Wesleyan | 31 | at | Alderson-Broaddus | 30 | | | |
| UNC Pembroke | 21 | at | Charleston WV | 70 | | | |
| Glenville State | 16 | at | Notre Dame OH | 38 | | | |
| Wheeling | 42 | at | West Liberty | 21 | | | |
| Concord | 38 | at | West Virginia State | 56 | | | |
| 10/29/2022 | Wheeling | 31 | at | Concord | 62 | | | |
| Notre Dame OH | 30 | at | Fairmont State | 6 | | | |
| Alderson-Broaddus | 7 | at | Frostburg State | 58 | | | |
| West Virginia State | 30 | at | Glenville State | 31 | | | |
| West Liberty | 3 | at | UNC Pembroke | 24 | | | |
| Charleston WV | 44 | at | West Virginia Wesleyan | 0 | | | |
| 11/5/2022 | Alderson-Broaddus | 13 | at | Concord | 50 | | | |
| Glenville State | 38 | at | Fairmont State | 36 | | | |
| UNC Pembroke | 0 | at | Notre Dame OH | 27 | | | |
| West Liberty | 32 | at | West Virginia State | 42 | | | |
| Charleston WV | 22 | at | Wheeling | 19 | | | |
| Frostburg State | 37 | at | West Virginia Wesleyan | 0 | | | |
| 11/12/2022 | Notre Dame OH | 27 | at | Alderson-Broaddus | 3 | | | |
| West Virginia State | 42 | at | Charleston WV | 35 | | | |
| West Virginia Wesleyan | 14 | at | Glenville State | 27 | | | |
| Concord | 58 | at | UNC Pembroke | 56 | 4OT | | |
| Frostburg State | 28 | at | West Liberty | 23 | | | |
| Fairmont State | 28 | at | Wheeling | 31 | OT | | |
| 11/19/2022 | Notre Dame OH | 13 | at | Ashland | 20 | | D2 Championship Round 1 | @ GMAC |