| 8/28/2021 | Madonna (0-8,0-8) | 7 | at | Lawrence Tech | 26 | |||
| 9/4/2021 | Lawrence Tech | 21 | at | Bluefield St WV (3-3) | 14 | at D2Ind | ||
| 9/11/2021 | Lawrence Tech | at | Kentucky Christian (3-7) | Cancelled | at MSC | |||
| 9/18/2021 | Saint Ambrose (4-7,3-6) | 24 | at | Lawrence Tech | 29 | |||
| 9/25/2021 | Lawrence Tech | at | Roosevelt (4-4,3-4) | Cancelled | ||||
| 10/9/2021 | Lawrence Tech | 31 | at | Taylor (2-8,2-7) | 3 | |||
| 10/16/2021 | Lawrence Tech | 0 | at | Indiana Wesleyan (7-1,6-1) | 35 | |||
| 10/23/2021 | Siena Heights (4-5,4-5) | at | Lawrence Tech | Cancelled | ||||
| 10/30/2021 | Concordia MI (9-2,9-1) | 42 | at | Lawrence Tech | 21 | |||
| 11/6/2021 | Lawrence Tech | 31 | at | St Francis IN (3-6,3-6) | 28 | |||
| 11/13/2021 | Lawrence Tech | 7 | at | Marian IN (9-3,8-1) | 41 |
| vs Lawrence Tech | vs Other Opponents | Lawrence Tech compared to OOs | |
| Record: | 3-5 | 45-49 | |
| Points Scored: | 24.25 | 25.31 | 1.06 |
| Points Allowed: | 20.75 | 26.98 | -6.23 |
| Margin: | 3.50 | -1.67 | -5.17 |
| Total Points: | 45.00 | 52.29 | -7.29 |