| 8/28/2021 | Mayville State (2-9) | 32 | at | Roosevelt | 37 | NSAA | ||
| 9/18/2021 | Roosevelt | 14 | at | Concordia MI (9-2,9-1) | 16 | |||
| 9/25/2021 | Lawrence Tech (5-3,4-3) | at | Roosevelt | Cancelled | ||||
| 10/2/2021 | St Xavier (7-3,7-2) | vs | Roosevelt | Canceled | ||||
| 10/9/2021 | Roosevelt | 34 | at | Missouri Baptist (4-7,2-7) | 17 | |||
| 10/16/2021 | Trinity International (3-6,1-6) | 14 | at | Roosevelt | 49 | |||
| 10/23/2021 | Roosevelt | 20 | at | Judson (4-7,4-6) | 30 | |||
| 10/30/2021 | Saint Ambrose (4-7,3-6) | 21 | at | Roosevelt | 35 | |||
| 11/6/2021 | St Francis IL (6-3,6-3) | 14 | at | Roosevelt | 0 | |||
| 11/13/2021 | Roosevelt | 7 | at | Olivet Nazarene (7-3,7-3) | 14 |
| vs Roosevelt | vs Other Opponents | Roosevelt compared to OOs | |
| Record: | 4-4 | 47-46 | |
| Points Scored: | 19.75 | 26.26 | 6.51 |
| Points Allowed: | 24.50 | 26.99 | -2.49 |
| Margin: | -4.75 | -0.73 | 4.02 |
| Total Points: | 44.25 | 53.25 | -9.00 |