| 8/28/2021 | Iowa Wesleyan (2-9) | 13 | at | Saint Ambrose | 45 | NAIAInd | ||
| 9/4/2021 | Waldorf (7-3) | 24 | at | Saint Ambrose | 17 | NSAA | ||
| 9/11/2021 | Concordia MI (9-2,9-1) | 34 | at | Saint Ambrose | 14 | |||
| 9/18/2021 | Saint Ambrose | 24 | at | Lawrence Tech (5-3,4-3) | 29 | |||
| 10/2/2021 | Trinity International (3-6,1-6) | 28 | at | Saint Ambrose | 49 | |||
| 10/9/2021 | Saint Ambrose | 28 | at | Judson (4-7,4-6) | 34 | OT | ||
| 10/16/2021 | Saint Ambrose | 17 | at | Olivet Nazarene (7-3,7-3) | 10 | |||
| 10/23/2021 | St Francis IL (6-3,6-3) | 35 | at | Saint Ambrose | 14 | |||
| 10/30/2021 | Saint Ambrose | 21 | at | Roosevelt (4-4,3-4) | 35 | |||
| 11/6/2021 | St Xavier (7-3,7-2) | 40 | at | Saint Ambrose | 13 | |||
| 11/13/2021 | Saint Ambrose | 35 | at | Missouri Baptist (4-7,2-7) | 23 |
| vs Saint Ambrose | vs Other Opponents | Saint Ambrose compared to OOs | |
| Record: | 7-4 | 51-46 | |
| Points Scored: | 27.73 | 25.49 | -2.24 |
| Points Allowed: | 25.18 | 26.05 | -0.87 |
| Margin: | 2.55 | -0.56 | -3.11 |
| Total Points: | 52.91 | 51.54 | 1.37 |