| 8/28/2021 | Madonna | 7 | at | Lawrence Tech (5-3,4-3) | 26 | |||
| 9/11/2021 | Marian IN (9-3,8-1) | 80 | at | Madonna | 3 | |||
| 9/18/2021 | Madonna | 24 | at | Missouri Baptist (4-7,2-7) | 42 | |||
| 9/25/2021 | Judson (4-7,4-6) | 41 | at | Madonna | 14 | |||
| 10/9/2021 | Madonna | 0 | at | St Francis IN (3-6,3-6) | 68 | |||
| 10/16/2021 | Madonna | 6 | at | Siena Heights (4-5,4-5) | 71 | |||
| 10/23/2021 | Taylor (2-8,2-7) | 63 | at | Madonna | 0 | |||
| 11/6/2021 | Madonna | 6 | at | Concordia MI (9-2,9-1) | 58 | |||
| 11/13/2021 | Indiana Wesleyan (7-1,6-1) | at | Madonna | Forfeit |
| vs Madonna | vs Other Opponents | Madonna compared to OOs | |
| Record: | 8-0 | 39-42 | |
| Points Scored: | 56.13 | 24.01 | -32.12 |
| Points Allowed: | 7.50 | 25.98 | -18.48 |
| Margin: | 48.63 | -1.97 | -50.60 |
| Total Points: | 63.63 | 49.99 | 13.64 |