| 9/2/2021 | Kentucky Christian | 7 | at | Cumberlands KY (6-4,6-4) | 58 | |||
| 9/11/2021 | Lawrence Tech (5-3) | at | Kentucky Christian | Cancelled | MSFA | |||
| 9/18/2021 | Kentucky Christian | 21 | at | Warner U. (3-8,3-7) | 27 | |||
| 9/25/2021 | Ave Maria (5-6,5-5) | 19 | at | Kentucky Christian | 20 | |||
| 10/2/2021 | Kentucky Christian | 25 | at | Union KY (2-7,2-7) | 21 | |||
| 10/9/2021 | Keiser (9-3,9-3) | 24 | at | Kentucky Christian | 16 | |||
| 10/16/2021 | Kentucky Christian | 24 | at | St Andrews (1-9,1-8) | 35 | |||
| 10/23/2021 | Point (2-9,2-7) | 22 | at | Kentucky Christian | 25 | |||
| 10/30/2021 | Bluefield (6-5,5-5) | 44 | at | Kentucky Christian | 23 | |||
| 11/6/2021 | Kentucky Christian | 20 | at | Faulkner (7-2,7-2) | 38 | |||
| 11/13/2021 | Reinhardt (9-3,9-2) | 49 | at | Kentucky Christian | 15 |
| vs Kentucky Christian | vs Other Opponents | Kentucky Christian compared to OOs | |
| Record: | 7-3 | 48-56 | |
| Points Scored: | 33.70 | 27.54 | -6.16 |
| Points Allowed: | 19.60 | 31.59 | -11.99 |
| Margin: | 14.10 | -4.05 | -18.15 |
| Total Points: | 53.30 | 59.13 | -5.83 |