| 9/4/2021 | Siena Heights | 17 | at | Olivet Nazarene (7-3,7-3) | 20 | |||
| 9/18/2021 | St Xavier (7-3,7-2) | 20 | at | Siena Heights | 13 | |||
| 9/25/2021 | St Francis IL (6-3,6-3) | 8 | at | Siena Heights | 13 | |||
| 10/2/2021 | Siena Heights | 27 | at | St Francis IN (3-6,3-6) | 17 | |||
| 10/9/2021 | Siena Heights | 10 | at | Concordia MI (9-2,9-1) | 20 | |||
| 10/16/2021 | Madonna (0-8,0-8) | 6 | at | Siena Heights | 71 | |||
| 10/23/2021 | Siena Heights | at | Lawrence Tech (5-3,4-3) | Cancelled | ||||
| 10/30/2021 | Siena Heights | 10 | at | Indiana Wesleyan (7-1,6-1) | 27 | |||
| 11/6/2021 | Marian IN (9-3,8-1) | 28 | at | Siena Heights | 6 | |||
| 11/13/2021 | Taylor (2-8,2-7) | 23 | at | Siena Heights | 51 |
| vs Siena Heights | vs Other Opponents | Siena Heights compared to OOs | |
| Record: | 5-4 | 50-36 | |
| Points Scored: | 18.78 | 28.38 | 9.60 |
| Points Allowed: | 24.22 | 25.08 | -0.86 |
| Margin: | -5.44 | 3.30 | 8.74 |
| Total Points: | 43.00 | 53.46 | -10.46 |