| 9/4/2021 | Lawrence Tech (5-3) | 21 | at | Bluefield St WV | 14 | MSFA (NAIA) | ||
| 9/11/2021 | Bluefield St WV | 35 | at | Elizabeth City State (3-7) | 27 | at CIAA | ||
| 9/18/2021 | Bluefield St WV | 20 | at | Johnson C Smith (1-7) | 12 | at CIAA | ||
| 10/9/2021 | Fort Lauderdale (0-7) | 9 | at | Bluefield St WV | 23 | None (Unk?) | ||
| 10/16/2021 | Bluefield St WV | 19 | at | Erskine (3-8,1-1) | 24 | |||
| 10/30/2021 | Bluefield St WV | 7 | at | Barton (6-5,2-0) | 62 | |||
| 11/13/2021 | Saint Anselm (3-6) | at | Bluefield St WV | Cancelled | NE10 |
| vs Bluefield St WV | vs Other Opponents | Bluefield St WV compared to OOs | |
| Record: | 3-3 | 18-40 | |
| Points Scored: | 25.83 | 19.86 | -5.97 |
| Points Allowed: | 19.67 | 35.48 | -15.81 |
| Margin: | 6.16 | -15.62 | -21.78 |
| Total Points: | 45.50 | 55.34 | -9.84 |