| 8/28/2021 | Lyon (2-8) | 14 | at | Missouri Baptist | 31 | Soon | ||
| 9/4/2021 | Missouri Baptist | 31 | at | Iowa Wesleyan (2-9) | 7 | at NAIAInd | ||
| 9/18/2021 | Madonna (0-8,0-8) | 24 | at | Missouri Baptist | 42 | |||
| 9/25/2021 | Missouri Baptist | 0 | at | Marian IN (9-3,8-1) | 49 | |||
| 10/2/2021 | Missouri Baptist | 13 | at | St Francis IL (6-3,6-3) | 20 | |||
| 10/9/2021 | Roosevelt (4-4,3-4) | 34 | at | Missouri Baptist | 17 | |||
| 10/16/2021 | St Xavier (7-3,7-2) | 31 | at | Missouri Baptist | 16 | |||
| 10/23/2021 | Missouri Baptist | 16 | at | Olivet Nazarene (7-3,7-3) | 37 | |||
| 10/30/2021 | Missouri Baptist | 14 | at | Trinity International (3-6,1-6) | 21 | |||
| 11/6/2021 | Judson (4-7,4-6) | 22 | at | Missouri Baptist | 28 | |||
| 11/13/2021 | Saint Ambrose (4-7,3-6) | 35 | at | Missouri Baptist | 23 |
| vs Missouri Baptist | vs Other Opponents | Missouri Baptist compared to OOs | |
| Record: | 7-4 | 41-57 | |
| Points Scored: | 26.73 | 24.49 | -2.24 |
| Points Allowed: | 21.00 | 30.83 | -9.83 |
| Margin: | 5.73 | -6.34 | -12.07 |
| Total Points: | 47.73 | 55.32 | -7.59 |