| 9/4/2021 | Millikin (3-7) | 33 | at | Greenville | 37 | CCIW | ||
| 9/11/2021 | Greenville | 57 | at | Rockford (2-8) | 42 | at NAC | ||
| 9/18/2021 | Greenville | 28 | at | Adrian (5-5) | 41 | at MIAA | ||
| 9/25/2021 | Greenville | 21 | at | Trinity International (3-6) | 26 | at MSFA | ||
| 10/2/2021 | Greenville | 21 | at | Martin Luther (5-4,4-1) | 14 | OT | ||
| 10/9/2021 | Northwestern MN (3-7,2-3) | 23 | at | Greenville | 35 | |||
| 10/16/2021 | Greenville | 42 | at | Westminster MO (3-5,1-4) | 14 | |||
| 10/30/2021 | Crown (1-9,0-6) | 30 | at | Greenville | 55 | |||
| 11/6/2021 | Greenville | 28 | at | Finlandia (0-9) | 2 | at MIAA | ||
| 11/13/2021 | Minnesota-Morris (5-5,4-2) | 21 | at | Greenville | 47 | |||
| 11/20/2021 | Greenville | 7 | at | Wisconsin-Whitewater (13-1) | 69 | at WIAC |
| vs Greenville | vs Other Opponents | Greenville compared to OOs | |
| Record: | 3-8 | 40-58 | |
| Points Scored: | 28.64 | 26.14 | -2.50 |
| Points Allowed: | 34.36 | 33.01 | 1.35 |
| Margin: | -5.72 | -6.87 | -1.15 |
| Total Points: | 63.00 | 59.15 | 3.85 |