| 8/28/2021 | Briar Cliff (3-8) | 3 | at | Waldorf | 30 | GPAC | ||
| 9/4/2021 | Waldorf | 24 | at | Saint Ambrose (4-7) | 17 | at MSFA | ||
| 9/18/2021 | Waldorf | 7 | at | Valley City State (8-2,5-2) | 14 | |||
| 9/25/2021 | Waldorf | 38 | at | Presentation (0-11,0-7) | 22 | |||
| 10/2/2021 | Dakota State (6-4,4-3) | 21 | at | Waldorf | 26 | |||
| 10/9/2021 | Waldorf | 52 | at | Mayville State (2-9,1-6) | 51 | |||
| 10/23/2021 | Mayville State (2-9,1-6) | 19 | at | Waldorf | 39 | |||
| 10/30/2021 | Valley City State (8-2,5-2) | 21 | at | Waldorf | 14 | |||
| 11/6/2021 | Waldorf | 42 | at | Iowa Wesleyan (2-9) | 12 | at NAIAInd | ||
| 11/13/2021 | Dickinson State (8-3,7-0) | 48 | at | Waldorf | 7 |
| vs Waldorf | vs Other Opponents | Waldorf compared to OOs | |
| Record: | 3-7 | 38-55 | |
| Points Scored: | 22.80 | 24.69 | 1.89 |
| Points Allowed: | 27.90 | 31.53 | -3.63 |
| Margin: | -5.10 | -6.84 | -1.74 |
| Total Points: | 50.70 | 56.22 | -5.52 |