| 9/4/2021 | Savannah State | 7 | at | Valdosta State (12-2) | 53 | at GSC | ||
| 9/11/2021 | Livingstone (1-8) | 6 | at | Savannah State | 50 | CIAA | ||
| 9/18/2021 | Benedict (5-5,5-5) | 34 | at | Savannah State | 41 | |||
| 9/25/2021 | Morehouse (4-6,4-4) | 10 | at | Savannah State | 29 | |||
| 10/2/2021 | Savannah State | 21 | at | Kentucky State (7-4,6-2) | 17 | |||
| 10/9/2021 | Erskine (3-8) | 6 | at | Savannah State | 39 | D2Ind | ||
| 10/16/2021 | Clark Atlanta (2-8,1-7) | 14 | at | Savannah State | 49 | |||
| 10/23/2021 | Savannah State | 0 | at | Albany State GA (10-2,8-0) | 30 | |||
| 10/30/2021 | Savannah State | 24 | at | Fort Valley State (5-5,5-4) | 6 | |||
| 11/6/2021 | Edward Waters (4-7,3-7) | 0 | at | Savannah State | 24 |
| vs Savannah State | vs Other Opponents | Savannah State compared to OOs | |
| Record: | 2-8 | 51-47 | |
| Points Scored: | 17.60 | 25.97 | 8.37 |
| Points Allowed: | 28.40 | 24.57 | 3.83 |
| Margin: | -10.80 | 1.40 | 12.20 |
| Total Points: | 46.00 | 50.54 | -4.54 |