| 9/4/2021 | Bluffton | 6 | at | Alma (5-5) | 24 | at MIAA | ||
| 9/11/2021 | St Vincent (5-6) | 34 | at | Bluffton | 14 | TPAC | ||
| 9/18/2021 | Bluffton | 21 | at | Kalamazoo (1-9) | 20 | at MIAA | ||
| 10/2/2021 | Mt St Joseph (6-4,5-2) | 45 | at | Bluffton | 27 | |||
| 10/9/2021 | Bluffton | 32 | at | Anderson (1-9,1-6) | 20 | |||
| 10/16/2021 | Bluffton | 6 | at | Franklin (6-4,4-3) | 45 | |||
| 10/23/2021 | Hanover (5-5,4-3) | 41 | at | Bluffton | 10 | |||
| 10/30/2021 | Bluffton | 12 | at | Rose-Hulman (8-3,7-0) | 48 | |||
| 11/6/2021 | Manchester (3-7,3-4) | 7 | at | Bluffton | 31 | |||
| 11/13/2021 | Bluffton | 30 | at | Defiance (1-9,1-6) | 12 |
| vs Bluffton | vs Other Opponents | Bluffton compared to OOs | |
| Record: | 6-4 | 35-57 | |
| Points Scored: | 29.60 | 21.55 | -8.05 |
| Points Allowed: | 18.90 | 28.83 | -9.93 |
| Margin: | 10.70 | -7.28 | -17.98 |
| Total Points: | 48.50 | 50.38 | -1.88 |