| 9/4/2021 | Kalamazoo (1-9) | 24 | at | Oberlin | 17 | MIAA | ||
| 9/11/2021 | Ohio Wesleyan (8-2,7-2) | 62 | at | Oberlin | 6 | |||
| 9/18/2021 | Denison (6-4,6-3) | 59 | at | Oberlin | 12 | |||
| 9/25/2021 | Oberlin | 21 | at | Kenyon (3-7,3-6) | 24 | |||
| 10/2/2021 | Wooster (6-4,5-4) | 28 | at | Oberlin | 24 | |||
| 10/9/2021 | Oberlin | 20 | at | Wabash (7-3,6-3) | 49 | |||
| 10/16/2021 | Wittenberg (7-3,7-2) | 44 | at | Oberlin | 27 | |||
| 10/23/2021 | Oberlin | 31 | at | Hiram (1-9,0-9) | 28 | |||
| 11/6/2021 | Oberlin | 13 | at | DePauw (9-3,8-1) | 66 | |||
| 11/13/2021 | Oberlin | 38 | at | Allegheny (3-7,2-7) | 42 |
| vs Oberlin | vs Other Opponents | Oberlin compared to OOs | |
| Record: | 9-1 | 42-50 | |
| Points Scored: | 42.60 | 26.51 | -16.09 |
| Points Allowed: | 20.90 | 30.14 | -9.24 |
| Margin: | 21.70 | -3.63 | -25.33 |
| Total Points: | 63.50 | 56.65 | 6.85 |