| 9/4/2021 | Washington & Jefferson | 21 | at | John Carroll (7-3) | 14 | at OAC | ||
| 9/11/2021 | Washington & Jefferson | 64 | at | Thiel (0-10,0-9) | 12 | |||
| 9/18/2021 | Bethany WV (1-9,1-8) | 3 | at | Washington & Jefferson | 28 | |||
| 9/25/2021 | Washington & Jefferson | 37 | at | Case Western Reserve (6-4,5-4) | 14 | |||
| 10/2/2021 | Washington & Jefferson | 24 | at | Geneva (4-6,4-5) | 20 | |||
| 10/9/2021 | St Vincent (5-6,4-5) | 22 | at | Washington & Jefferson | 63 | |||
| 10/23/2021 | Westminster PA (8-3,8-1) | 23 | at | Washington & Jefferson | 18 | |||
| 10/30/2021 | Washington & Jefferson | 28 | at | Grove City (8-3,6-3) | 24 | |||
| 11/6/2021 | Washington & Jefferson | 11 | at | Carnegie Mellon (8-2,8-1) | 27 | |||
| 11/13/2021 | Waynesburg (2-8,2-7) | 0 | at | Washington & Jefferson | 55 | |||
| 11/20/2021 | Washington & Jefferson | 7 | at | Brockport State (8-3) | 20 | at E8 |
| vs Washington & Jefferson | vs Other Opponents | Washington & Jefferson compared to OOs | |
| Record: | 3-8 | 54-49 | |
| Points Scored: | 16.27 | 26.31 | 10.04 |
| Points Allowed: | 32.36 | 24.74 | 7.62 |
| Margin: | -16.09 | 1.57 | 17.66 |
| Total Points: | 48.63 | 51.05 | -2.42 |