| 9/4/2021 | Newberry (10-3) | 31 | at | Barton | 7 | SAC | ||
| 9/11/2021 | Barton | 38 | at | Erskine (3-8,1-1) | 25 | |||
| 9/18/2021 | Barton | 10 | at | Catawba (5-4) | 17 | at SAC | ||
| 9/25/2021 | Barton | 45 | at | Limestone (0-9) | 7 | at SAC | ||
| 10/2/2021 | Carson-Newman (1-9) | 17 | at | Barton | 31 | SAC | ||
| 10/9/2021 | Barton | 32 | at | Mars Hill (8-3) | 40 | at SAC | ||
| 10/16/2021 | Wingate (7-3) | 20 | at | Barton | 26 | OT | SAC | |
| 10/23/2021 | Barton | 17 | at | Tusculum (5-6) | 41 | at SAC | ||
| 10/30/2021 | Bluefield St WV (3-3,0-2) | 7 | at | Barton | 62 | |||
| 11/6/2021 | Lenoir-Rhyne (8-3) | 56 | at | Barton | 20 | SAC | ||
| 11/13/2021 | Barton | 36 | at | Virginia-Wise (5-6) | 24 | at SAC |
| vs Barton | vs Other Opponents | Barton compared to OOs | |
| Record: | 5-6 | 50-51 | |
| Points Scored: | 25.91 | 25.89 | -0.02 |
| Points Allowed: | 29.45 | 25.58 | 3.87 |
| Margin: | -3.54 | 0.31 | 3.85 |
| Total Points: | 55.36 | 51.47 | 3.89 |