| 9/2/2021 | West Georgia (9-3) | 45 | at | Carson-Newman | 7 | GSC | ||
| 9/18/2021 | Wingate (7-3,5-2) | 25 | at | Carson-Newman | 3 | |||
| 9/25/2021 | Carson-Newman | 7 | at | Virginia-Wise (5-6,4-4) | 33 | |||
| 10/2/2021 | Carson-Newman | 17 | at | Barton (6-5) | 31 | at D2Ind | ||
| 10/9/2021 | Carson-Newman | 27 | at | Catawba (5-4,2-4) | 33 | |||
| 10/16/2021 | Lenoir-Rhyne (8-3,6-2) | 59 | at | Carson-Newman | 0 | |||
| 10/23/2021 | Carson-Newman | 3 | at | Newberry (10-3,7-1) | 34 | |||
| 10/30/2021 | Mars Hill (8-3,6-2) | 49 | at | Carson-Newman | 23 | |||
| 11/6/2021 | Limestone (0-9,0-7) | 21 | at | Carson-Newman | 27 | |||
| 11/13/2021 | Carson-Newman | 13 | at | Tusculum (5-6,3-5) | 48 |
| vs Carson-Newman | vs Other Opponents | Carson-Newman compared to OOs | |
| Record: | 9-1 | 54-44 | |
| Points Scored: | 37.80 | 28.45 | -9.35 |
| Points Allowed: | 12.70 | 24.28 | -11.58 |
| Margin: | 25.10 | 4.17 | -20.93 |
| Total Points: | 50.50 | 52.73 | -2.23 |