| 9/2/2021 | Chowan (7-3) | 30 | at | Mars Hill | 24 | OT | CIAA | |
| 9/9/2021 | Virginia U-Lynchburg (2-9) | 14 | at | Mars Hill | 50 | None (Unk?) | ||
| 9/18/2021 | Virginia-Wise (5-6,4-4) | 9 | at | Mars Hill | 44 | |||
| 9/25/2021 | Mars Hill | 16 | at | Lenoir-Rhyne (8-3,6-2) | 31 | |||
| 10/2/2021 | Newberry (10-3,7-1) | 22 | at | Mars Hill | 28 | 2OT | ||
| 10/9/2021 | Barton (6-5) | 32 | at | Mars Hill | 40 | D2Ind | ||
| 10/16/2021 | Mars Hill | 32 | at | Limestone (0-9,0-7) | 3 | |||
| 10/23/2021 | Catawba (5-4,2-4) | 14 | at | Mars Hill | 31 | |||
| 10/30/2021 | Mars Hill | 49 | at | Carson-Newman (1-9,1-7) | 23 | |||
| 11/6/2021 | Tusculum (5-6,3-5) | 7 | at | Mars Hill | 20 | |||
| 11/13/2021 | Mars Hill | 19 | at | Wingate (7-3,5-2) | 26 |
| vs Mars Hill | vs Other Opponents | Mars Hill compared to OOs | |
| Record: | 3-8 | 53-52 | |
| Points Scored: | 19.18 | 27.27 | 8.09 |
| Points Allowed: | 32.09 | 26.82 | 5.27 |
| Margin: | -12.91 | 0.45 | 13.36 |
| Total Points: | 51.27 | 54.09 | -2.82 |