| 9/4/2021 | Limestone | 16 | at | North Greenville (5-6) | 37 | at GSC | ||
| 9/11/2021 | St Augustine's (1-7) | at | Limestone | Cancelled | CIAA | |||
| 9/18/2021 | Limestone | 21 | at | Tusculum (5-6,3-5) | 24 | |||
| 9/25/2021 | Barton (6-5) | 45 | at | Limestone | 7 | D2Ind | ||
| 10/2/2021 | Limestone | at | Catawba (5-4,2-4) | Canceled | ||||
| 10/9/2021 | Wingate (7-3,5-2) | 35 | at | Limestone | 17 | |||
| 10/16/2021 | Mars Hill (8-3,6-2) | 32 | at | Limestone | 3 | |||
| 10/23/2021 | Limestone | 3 | at | Lenoir-Rhyne (8-3,6-2) | 45 | |||
| 10/30/2021 | Virginia-Wise (5-6,4-4) | 28 | at | Limestone | 24 | |||
| 11/6/2021 | Limestone | 21 | at | Carson-Newman (1-9,1-7) | 27 | |||
| 11/13/2021 | Newberry (10-3,7-1) | 42 | at | Limestone | 7 |
| vs Limestone | vs Other Opponents | Limestone compared to OOs | |
| Record: | 9-0 | 52-55 | |
| Points Scored: | 35.00 | 26.17 | -8.83 |
| Points Allowed: | 13.22 | 26.29 | -13.07 |
| Margin: | 21.78 | -0.12 | -21.90 |
| Total Points: | 48.22 | 52.46 | -4.24 |