| 9/4/2021 | Lenoir-Rhyne | 48 | at | Virginia State (3-6) | 7 | at CIAA | ||
| 9/18/2021 | Lenoir-Rhyne | 21 | at | Newberry (10-3,7-1) | 28 | |||
| 9/25/2021 | Mars Hill (8-3,6-2) | 16 | at | Lenoir-Rhyne | 31 | |||
| 10/2/2021 | Lenoir-Rhyne | 28 | at | Virginia-Wise (5-6,4-4) | 35 | |||
| 10/9/2021 | Tusculum (5-6,3-5) | 31 | at | Lenoir-Rhyne | 38 | |||
| 10/16/2021 | Lenoir-Rhyne | 59 | at | Carson-Newman (1-9,1-7) | 0 | |||
| 10/23/2021 | Limestone (0-9,0-7) | 3 | at | Lenoir-Rhyne | 45 | |||
| 10/30/2021 | Lenoir-Rhyne | 31 | at | Wingate (7-3,5-2) | 6 | |||
| 11/6/2021 | Lenoir-Rhyne | 56 | at | Barton (6-5) | 20 | at D2Ind | ||
| 11/13/2021 | Catawba (5-4,2-4) | 3 | at | Lenoir-Rhyne | 56 | |||
| 11/20/2021 | Lenoir-Rhyne | 10 | at | Bowie State (12-2) | 31 | at CIAA |
| vs Lenoir-Rhyne | vs Other Opponents | Lenoir-Rhyne compared to OOs | |
| Record: | 3-8 | 59-48 | |
| Points Scored: | 16.36 | 27.22 | 10.86 |
| Points Allowed: | 38.45 | 22.94 | 15.51 |
| Margin: | -22.09 | 4.28 | 26.37 |
| Total Points: | 54.81 | 50.16 | 4.65 |