| 9/2/2021 | Shaw (6-4) | 7 | at | Wingate | 30 | CIAA | ||
| 9/11/2021 | Fayetteville State (8-2) | 21 | at | Wingate | 40 | CIAA | ||
| 9/18/2021 | Wingate | 25 | at | Carson-Newman (1-9,1-7) | 3 | |||
| 9/25/2021 | Catawba (5-4,2-4) | at | Wingate | Cancelled | ||||
| 10/2/2021 | Tusculum (5-6,3-5) | 35 | at | Wingate | 43 | |||
| 10/9/2021 | Wingate | 35 | at | Limestone (0-9,0-7) | 17 | |||
| 10/16/2021 | Wingate | 20 | at | Barton (6-5) | 26 | OT | at D2Ind | |
| 10/23/2021 | Wingate | 48 | at | Virginia-Wise (5-6,4-4) | 21 | |||
| 10/30/2021 | Lenoir-Rhyne (8-3,6-2) | 31 | at | Wingate | 6 | |||
| 11/6/2021 | Wingate | 35 | at | Newberry (10-3,7-1) | 41 | 2OT | ||
| 11/13/2021 | Mars Hill (8-3,6-2) | 19 | at | Wingate | 26 |
| vs Wingate | vs Other Opponents | Wingate compared to OOs | |
| Record: | 3-7 | 59-47 | |
| Points Scored: | 22.10 | 27.28 | 5.18 |
| Points Allowed: | 30.80 | 22.43 | 8.37 |
| Margin: | -8.70 | 4.85 | 13.55 |
| Total Points: | 52.90 | 49.71 | 3.19 |