| 9/4/2021 | Newberry | 31 | at | Barton (6-5) | 7 | at D2Ind | ||
| 9/11/2021 | North Greenville (5-6) | 24 | at | Newberry | 14 | GSC | ||
| 9/18/2021 | Lenoir-Rhyne (8-3,6-2) | 21 | at | Newberry | 28 | |||
| 9/25/2021 | Newberry | 24 | at | Tusculum (5-6,3-5) | 19 | |||
| 10/2/2021 | Newberry | 22 | at | Mars Hill (8-3,6-2) | 28 | 2OT | ||
| 10/9/2021 | Newberry | 37 | at | Virginia-Wise (5-6,4-4) | 14 | |||
| 10/16/2021 | Catawba (5-4,2-4) | 7 | at | Newberry | 14 | |||
| 10/23/2021 | Carson-Newman (1-9,1-7) | 3 | at | Newberry | 34 | |||
| 10/30/2021 | Newberry | 48 | at | Erskine (3-8) | 10 | at D2Ind | ||
| 11/6/2021 | Wingate (7-3,5-2) | 35 | at | Newberry | 41 | 2OT | ||
| 11/13/2021 | Newberry | 42 | at | Limestone (0-9,0-7) | 7 | |||
| 11/20/2021 | Newberry | 33 | at | West Florida (9-2) | 30 | OT | at GSC | |
| 11/27/2021 | Newberry | 10 | at | Bowie State (12-2) | 13 | at CIAA |
| vs Newberry | vs Other Opponents | Newberry compared to OOs | |
| Record: | 3-10 | 71-56 | |
| Points Scored: | 16.77 | 29.55 | 12.78 |
| Points Allowed: | 29.08 | 25.41 | 3.67 |
| Margin: | -12.31 | 4.14 | 16.45 |
| Total Points: | 45.85 | 54.96 | -9.11 |