| 9/4/2021 | Fayetteville State | 47 | vs | Elizabeth City State (3-7,3-5) | 6 | Rocky Mount NC | ||
| 9/11/2021 | Fayetteville State | 21 | at | Wingate (7-3) | 40 | at SAC | ||
| 9/25/2021 | Virginia State (3-6,3-4) | 14 | at | Fayetteville State | 28 | |||
| 10/2/2021 | Lincoln PA (1-9,1-6) | 9 | at | Fayetteville State | 46 | |||
| 10/9/2021 | Fayetteville State | 15 | at | Shaw (6-4,5-2) | 12 | |||
| 10/16/2021 | Johnson C Smith (1-7,1-5) | 12 | at | Fayetteville State | 55 | |||
| 10/23/2021 | Fayetteville State | 40 | at | St Augustine's (1-7,1-6) | 12 | |||
| 10/30/2021 | Livingstone (1-8,1-5) | 0 | at | Fayetteville State | 34 | |||
| 11/6/2021 | Winston-Salem State (3-6,3-4) | 3 | at | Fayetteville State | 10 | |||
| 11/13/2021 | Bowie State (12-2,8-0) | 17 | at | Fayetteville State | 7 |
| vs Fayetteville State | vs Other Opponents | Fayetteville State compared to OOs | |
| Record: | 2-8 | 36-51 | |
| Points Scored: | 12.50 | 20.38 | 7.88 |
| Points Allowed: | 30.30 | 24.80 | 5.50 |
| Margin: | -17.80 | -4.42 | 13.38 |
| Total Points: | 42.80 | 45.18 | -2.38 |