| 9/4/2021 | Tusculum (5-6) | 58 | at | St Augustine's | 14 | SAC | ||
| 9/11/2021 | St Augustine's | at | Limestone (0-9) | Cancelled | at SAC | |||
| 9/25/2021 | Chowan (7-3,4-3) | 59 | at | St Augustine's | 12 | |||
| 10/2/2021 | St Augustine's | 9 | at | Virginia State (3-6,3-4) | 33 | |||
| 10/9/2021 | St Augustine's | 7 | at | Livingstone (1-8,1-5) | 21 | |||
| 10/16/2021 | St Augustine's | 0 | at | Winston-Salem State (3-6,3-4) | 41 | |||
| 10/23/2021 | Fayetteville State (8-2,8-1) | 40 | at | St Augustine's | 12 | |||
| 10/30/2021 | St Augustine's | 13 | at | Johnson C Smith (1-7,1-5) | 34 | |||
| 11/6/2021 | Shaw (6-4,5-2) | 17 | at | St Augustine's | 21 |
| vs St Augustine's | vs Other Opponents | St Augustine's compared to OOs | |
| Record: | 7-1 | 27-50 | |
| Points Scored: | 37.88 | 21.94 | -15.94 |
| Points Allowed: | 11.00 | 24.83 | -13.83 |
| Margin: | 26.88 | -2.89 | -29.77 |
| Total Points: | 48.88 | 46.77 | 2.11 |