| 9/4/2021 | Lenoir-Rhyne (8-3) | 48 | at | Virginia State | 7 | SAC | ||
| 9/11/2021 | Virginia State | 7 | at | Ohio Dominican (7-4) | 10 | at GMAC | ||
| 9/25/2021 | Virginia State | 14 | at | Fayetteville State (8-2,8-1) | 28 | |||
| 10/2/2021 | St Augustine's (1-7,1-6) | 9 | at | Virginia State | 33 | |||
| 10/9/2021 | Elizabeth City State (3-7,3-5) | 7 | at | Virginia State | 35 | |||
| 10/16/2021 | Virginia State | 44 | at | Bowie State (12-2,8-0) | 51 | |||
| 10/23/2021 | Lincoln PA (1-9,1-6) | 3 | at | Virginia State | 23 | |||
| 10/30/2021 | Chowan (7-3,4-3) | 38 | at | Virginia State | 30 | |||
| 11/6/2021 | Virginia State | 13 | at | Virginia Union (6-4,5-2) | 20 |
| vs Virginia State | vs Other Opponents | Virginia State compared to OOs | |
| Record: | 6-3 | 47-38 | |
| Points Scored: | 23.78 | 26.38 | 2.60 |
| Points Allowed: | 22.89 | 23.15 | -0.26 |
| Margin: | 0.89 | 3.23 | 2.34 |
| Total Points: | 46.67 | 49.53 | -2.86 |