| 9/2/2021 | Central Washington (8-3) | 66 | at | Eastern New Mexico | 24 | GNWAC | ||
| 9/11/2021 | Adams State (1-10) | 14 | at | Eastern New Mexico | 42 | RMAC | ||
| 9/18/2021 | Texas A&M-Kingsville (5-5,3-4) | 36 | at | Eastern New Mexico | 10 | |||
| 9/25/2021 | Eastern New Mexico | 24 | at | Midwestern State (7-3,6-1) | 31 | OT | ||
| 10/2/2021 | Lincoln CA (1-9) | 6 | at | Eastern New Mexico | 52 | None (Unk?) | ||
| 10/9/2021 | Eastern New Mexico | 50 | at | Western New Mexico (1-9,0-7) | 47 | |||
| 10/16/2021 | West Texas A&M (7-4,5-2) | 44 | at | Eastern New Mexico | 24 | |||
| 10/23/2021 | Eastern New Mexico | 21 | at | Texas-Permian Basin (5-6,3-4) | 44 | |||
| 10/30/2021 | Angelo State (11-3,5-2) | 59 | at | Eastern New Mexico | 7 | |||
| 11/6/2021 | Eastern New Mexico | 70 | at | North American U (2-4) | 21 | at None | ||
| 11/13/2021 | Eastern New Mexico | 10 | at | Texas A&M-Commerce (7-4,5-2) | 30 |
| vs Eastern New Mexico | vs Other Opponents | Eastern New Mexico compared to OOs | |
| Record: | 7-4 | 48-56 | |
| Points Scored: | 36.18 | 27.57 | -8.61 |
| Points Allowed: | 30.36 | 29.21 | 1.15 |
| Margin: | 5.82 | -1.64 | -7.46 |
| Total Points: | 66.54 | 56.78 | 9.76 |